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DPP-4i=dipeptidyl peptidase-4 inhibitor

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They found that patients with type 2 diabetes starting oral semaglutide showed significant HbA1c average blood sugar levels and weight improvements after six months, especially those with a recent diabetes diagnosis

Under these conditions, the increased secretion of counterregulatory hormones stimulates FFAs oxidation in the liver and accelerates the production of ketone bodies, which are metabolized in muscle, adipose tissue and, most importantly, in heart and brain ( As demonstrated in a recent meta-analysis, SGLT-2i treatment is associated with increased plasma fasting glucagon levels in patients with diabetes compared with non-SGLT-2i treatments with a reduction of insulin and increased ketone body levels ( via GH upregulation

They have gained widespread attention for their effectiveness in treating type 2 diabetes and supporting weight management